Major HBR cases concerns on a whole industry, a whole organization or some part of organization; profitable or non-profitable organizations. To make a detailed case analysis, student should follow these steps: Case study method guide is provided to students which determine the aspects of problem needed to be considered while analyzing a case study. It is very important to have a thorough reading and understanding of guidelines provided.
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Rachel Stevenson August 7, CHEZ L02 Electrophilic Aromatic Substitution: Preparing p-Nitroacetanilide from Acetanilide Experiment performed July 31, Purpose The objective of the experiment was to conduct an electrophilic aromatic substitution reaction with acetanilide and a nitrating reagent to form p-nitroacetanilide (and simultaneously, the isomer o-nitroacetanilide)%(23). nitroniumionisattackedbytheconjugatedpi(systemof(thebenzenering(to(forman(barnweddingvt.combocationwillthenlose ahydrogenion(to(formthe. Nov 12, · USPCATALOG. USP continuously releases new Reference Standards. For daily updates and new listings, visit barnweddingvt.com Miami. Meet with USP at Industry Events Be sure to stop by the USP booth at EAS Ranga Reddy District Hyderabad A new section about International Cold Chain Shipments has been added to the.
Or getting something worthless for the Eas p nitroacetanilide we spent surfing. So I started this blog adding the science stuff I have noted which I think might help someone in their home work.
Basically it can be carried out by a mixture of concentrated nitric acid and sulphuric acid. Mixture is useful to obtain the active nitronium ion.
Electrophilic aromatic substitution is a method used when a functional group is needed to be substituted on to an aromatic compound. In the nitration, nitronium ion acts as the electrophile that involves the attack of the electron-rich Benzene ring. In this experiment nitration is carried out using acetanilide.
Theory Acetanilide displays moderately reactivity in electrophilic aromatic substitution. Principally, acetanilide gives Ortho and Para mono nitroacetanilides. This is due to the resonance delocalizing the benzene ring by nitrogen lone pair.
Therefore Ortho and Para positions are more resonance stabilized than the Meta. Acetanilide undergoes ready nitration giving mainly the colourless P-nitroacetanilide, mixed with much smaller proportion of the yellow colour O-nitroacetanilide.
H2SO4 was added to the mixture. H2SO4 was added drop wisely while stirring the viscous mixture continuously keeping the temperature below C. The beaker was rinsed with 10mL of water containing few fragments of ice and the solution was added to the main bulk of the product.
Conclusion The initial compounds used were known. Therefore according to those the final product should be nitroacetanilide. As the colour of the product was white, it should be Para nitroacetanilide.
Discussion Through the use of electrophilic aromatic substitution, acetanilide is nitrated to nitroacetanilide. There are several key steps involved in the nitration.
The first step of the reaction involved in the donation of an electron pair by the acetanilide to the eletrophile, the nitronium ion.
This nitronium ion was formed by the reaction of sulfuric and nitric acids. Basically the whole mechanism undergoes as below; Benzene is shown here instead of acetanilide Image via en. Also the addition of nitric acid is exothermic.
Therefore the mixture would get too hot exceeding the temperature range suitable for the nitration. To avoid this, the addition of HNO3 acid should be done very slowly, dropwisely. Cold temperatures were used to slowdown the reaction rate and help to avoid over nitration.
Glacial acetic acid is used because it is a polar solvent capable of dissolving acetanilide and the acetate ion is a poor nucleophile, so no substitution is possible. At the end, traces of acid should be removed because hydrogen ions catalyze the hydrolysis of the amide to p-nitroaniline. Acid is removed by pouring the mixture onto ice and water and filtering.
The melting point is determined to characterize the product. Theoretical melting point of the Para nitroacetanilide is found to be C.
The observed value was C and it is much lower than the theoretical values and can be accounted for impurities in the product.
Some impurities might be Ortho and Meta directing substances. Also there can be some experimental errors occurred during the experiment such as not controlling the exact temperatures mentioned for the reactions.Carbon 10 (a) Crude p-nitroacetanilide (b) Purified p-nitroacetanilide Figure 9(a)-(b).
Crude and recrystallised p-nitroacetanilide. Tasks & Questions • Calculate the theoretical and percentage yields of p-nitroacetanilide. • Record the 1H NMR spectra of acetanilide and p-nitroacetanilide using the Spinsolve NMR spectrometer. Oct 23, · This video discusses the reaction mechanism of p-nitroacetanilide as it converts into p-nitroaniline.
Skip navigation Sign in. Search. EAS vid 4 by Leah4sci - Duration: Leah4sci 51, The sequence of reactions shown on p. of your textbook is an example.
Full text of "Synthetic organic chemicals: United States production and sales" See other formats. Synthesis of p-Nitroacetanilide (electrophilic aromatic substitution) In this experiment, we convert acetanilide to p-nitroacetanilide. [pic] The mechanism for . (Deactivating) 4-nitroacetanilide Bromobenzene (Deactivating) Chlorobenzene (Deactivating) Mixture of bromo and chloro products Acetanilide (Strongly Activating) Toluene (Activating) 4-nitroacetanilide Acetanilide (Strongly Activating) Nitrobenzene (Very Strongly Deactivating) 4-nitroacetanilide.
The starting material is acetanilide. the target molecule is obtained as the final product. The target molecule in this experiment is a sulfa drug called sulfanilamide. (EAS). This reaction is used to place the second group.
Carbon 10 (a) Crude p-nitroacetanilide (b) Purified p-nitroacetanilide Figure 9(a)-(b). Crude and recrystallised p-nitroacetanilide. Tasks & Questions • Calculate the theoretical and percentage yields of p-nitroacetanilide.
• Record the 1H NMR spectra of acetanilide and p-nitroacetanilide using the Spinsolve NMR spectrometer. o Nitroacetanilide Mechanism EAS E lectrophilic A romatic S ubstitution 36 from CHEM chem at Louisiana State University.
Write equations for the hydrolysis of p-nitroacetanilide in (a) aqueous acid; (b) aqueous hydroxide. The products of the reaction should be p-nitroaniline and acetic acid (or acetate ion in base).